Abstract

This study relates to silica nanoparticle (SNP) platform that can either attach or penetrate tumor cells and only deliver singlet oxygen for photodynamic therapy (PDT) while conserving the embedded photosensitizers (PS). As a model we demonstrate the successful embedding of the PS meta(hydroxyphenyl)chlorin (m-THPC) in SNP that are based on silica matrix and show positive effects in terms of cytotoxicity and thus indirectly on the
singlet oxygen production. Singlet oxygen delivery by the photodynamic nanoparticles (PDT@SNP), as assessed from the observed cell damage, seems to
exceed that obtained from free PS molecules for a ten time less dose compared to the standard PDT dose.

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Contact

Amina Wirth
phone: +41 61 467 42 68
Email: amina.wirth@fhnw.ch