
Forschungsseminar Vorlesung von Paula Guerrero
Synthetic Glycolipids Rescue Biosynthesis Deficiencies of GPI-Anchored Protein, Paula Guerrero PhD Student, Institute for Chemistry and Bioanalytics, Hochschule für Life Sciences FHNW
The objective of this project was to employ synthetic GPI fragments to rescue the production of GPI-Anchored Proteins (GPI-APs) and treat Inherited GPI Disorders caused by mutations affecting the initial steps of the GPI biosynthesis. We designed and synthesized 5 glycolipids that resemble the products/substrates of the enzymes involved in those steps and, to our delight, they were efficiently incorporated into the treated cells and restored the GPI-APs expression.
Datum und Zeit
18.05.2022 12:30 - 13:15 iCal
Ort
Hörsaal 02.S.21
FHNW Campus Muttenz, Hofackerstrasse 30, 4132 Muttenz
Veranstaltet durch
Hochschule für Life Sciences
Kosten
Eintritt frei