NMR is a powerful and establish analytical method, which still relies on mostly manual interpretation of its spectra. While the simulation of NMR spectra is in the meantime quite accurate there is no pendant for the analysis. Such a capability is particularly interesting as it would allow to include NMR…
Alternative RNA splicing is a regulatory cellular mechanism to create multiple mRNA molecules from the same gene and is often disrupted in diseases. We could show in the international Pan-Cancer Analysis of Whole Genomes (PCAWG) study that such disruptions in alternative splicing patterns are widespread in cancer. By developing new…
Andrea BiederCell-based in vitro pharmacological assays are routinely used to identify new drug candidates and test drug safety. However, the standard models have limits regarding their physiological relevance. One powerful new tool is the use of organoids – stem-cell derived self-organizing cell assemblies, that mimic closely the physiology of…
To start the design of an orthosis or of a prosthesis, orthopedists commonly use plaster casting to acquire the patient’s limb shape. The rest of the design workflow is so far already digital. However, the limb shape acquisition is still analog, wet, inaccurate and time consuming. The Swiss startup BellwaldTec…
SuperPro Designer is a digital tool for modeling, evaluating and optimizing various batch and continuous processes in a wide range of industries such as biotechnology, pharmaceuticals, food processing, water purification, wastewater treatment, air pollution control, etc. With your designed model, you can obtain various information such as costs, feasibility, bottlenecks,…
Early and accurate disease diagnosis is crucial for stopping disease progression and identifying appropriate treatments, but precise diagnosis of autoimmune disease is notoriously challenging due to the non-specific symptoms: it can take 4 to 5 years and multiple visits to various physicians. However, an early and precise disease diagnosis is…
Computer-assisted modelling of wastewater treatment is becoming more and more popular and is particularly useful for the design and optimization of wastewater treatment plants. Popular models such as the Activated Sludge Model No. 3 (ASM3) consist of a series of differential equations which describe biochemical reactions which occur during biological…
Building accurate and robust Raman models for online monitoring of cell culture processes remains a difficult and time-consuming task. A novel offline calibration approach based on design-of-experiment spiking and multivariate data analysis was developed to monitor of several cell culture components simultaneously. Raman prediction models enabled real-time insight into the…