Projects

All Projects of the Institute for Pharma Technology in alphabetical order.

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  A new dynamic light scattering technique to analyze dispersions

  Introduction of a new modulated 3D cross-correlated dynamic light scattering instrument to enable product analytics of aggregating colloids and concentrated dispersions

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  A race against time

  Whether or not a drug helps, depends on more than just its active ingredient. That ingredient first has to get to the place where it needs to work. The new targeted drugs, however, require larger and more complex molecules. As a result, they are often poorly soluble and difficult to get from the gastrointestinal tract into the bloodstream. Therefore the HLS pharmacist Martin Kuentz is working on a reliable lipid-based system to transport poorly soluble drugs in dissolved form in the gastrointestinal tract.

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  Beer: good health!

  Beer is one of our most important drinks, both economically and culturally: the Swiss drank over 460 million litres of beer in 2015. It isn’t often said that beer is good for you but the hops which give beer its distinctive taste have a positive effect on health. Researchers at the HLS have discovered that prenylflavonoids in hops stabilize the gut wall and can counteract some illnesses.

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  Bio-enabling formulations

  Research and development on bio-enabling formulations as part of the EU-project PEARRL

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  InPharma

  InPharma has the goal of eliminating animals from the development of new oral drug formulations (EU funds MSCA-H2020 EID InPharma)

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  Intestinal Absorption Mechanism of Casearin X

  Intestinal Absorption Mechanism of Casearin X in Caco-2 Cells with Modified Carboxylesterase Activity

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  Intestinal drug absorption

  Bio-conjugation combined with efflux in the enterocyte determines intestinal drug absorption

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  Restoration of intestinal barrier integrity

  Effects of hops derived prenylflavonoids on TNF-α induced barrier dysfunction in intestinal epithelial cells.

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  Robot assistance in the laboratory

  A great many experiments are required before a medicinal substance can become a finished drug. Researchers must find the best combination of stabilisers and other additives and test whether a drug always works as intended. This process can be facilitated with an HLS robot system which enables reliable studies to be done on highly sensitive biomolecules. A newly developed software tool provides a clear overview of the results of individual experiments, thus accelerating the search for the optimal drug formulation.

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  Tablets: ice cold, bone dry and lightning fast

  Researchers from the HLS Institute for Pharma Technology, in cooperation with Rohrer AG in Möhlin, have developed a new manufacturing process for tablets that dissolve in the mouth in a few seconds – without any additional liquid.