Oral formulations of chemical drugs

Computational and analytical tools in Pharmaceutics for oral Drug Delivery

The research group of Prof. Kuentz is active in the field of oral dosage forms for mostly poorly water-soluble compounds. A focus is given on lipid-based drug delivery systems as well as solid drug dispersions to target enhanced solubilization and absorption. There are different formulation and process technologies available on a laboratory scale, which include among others, vacuum homogenization, micro particle prilling, hot melt extrusion, and spray drying.

New computer-based and analytical methods support a rational formulation design from molecular drug-excipient interactions to the microstructure of the final dosage form. Digital and analytical imaging approaches provide research tools to facilitate a modern version of Quality by Design for oral dosage forms.