Eckdaten
Tätigkeiten
- Arbeitsgruppenleiter Proteine und Enzyme
- Studiengangleiter MSc in Life Sciences
Kompetenzen
Forschungsgruppe
Proteine: Expression, Charakterisierung, Engineering; Extremophile Mikroorganismen, Mikrobiom; Bioinformatische Auswertungen
Proteine und Enzyme
Optimierung von Proteine für technische Anwendungen
- Institut
- Institut für Chemie und Bioanalytik
Forschungsförderungen
Forschungsförderungen
- 07/00 - 07/07 DFG grant, priority programme „Interface between material and biosystem“:
Influence of a nanoporous surface and of biofunctionalization upon biocompatibility towards bone cells, together with Prof. Dr. G. Ziegler (FBI, Bayreuth)
- 02/01 - 03/04 Grant by Bavarian high-tech initiative:
Production of thermostable and acidophilic enzymes for biotechnological purposes, together with Prof. G. Krauss (Department of Biochemistry, Bayreuth)
- 03/03 - 03/07 DFG grant, priority programme “Genome function and gene regulation in archaea”:
In vivo study of gene regulation and gene function in Sulfolobus ssp.: application and development of transformation vectors
- 02/04 - 01/07 DFG grant:
Structure and function of the gene products ORF8O and ORF904 from the plasmid pRN1 of the thermoacidophilic archaeon Sulfolobus islandicus
- 06/05 - 05/08 DFG grant:
Structure and function of the multifunctional replication protein from the plasmid pRN1 from Sulfolobus islandicus
- 10/06 - 09/09 DFG grant:
Study of an extremophilic β-endoglucanase
- 04/07 - 03/10 DFG grant:
Molecular mechanisms of archaeal DNA replication
- 04/12 - 12/15 SNF grant:
Structure and Function of a Primase, together with Prof. Dr. F. Allain (ETHZ)
- 12/12 – 09/15 CTI grant:
Identification of pharmacologic active compounds in the culture supernatant of a commensale E. coli, a commercial production, together with Laves AG
- 03/14 – 12/17 CTI grant:
Development of novel bacterial sortase enzymes for site-specific conjugation of payloads to antibodies, together with NBE Therapeutics
- 01/16 – 12/18 SNF grant:
Structure and Function of a Primase (prolongation), together with Prof. Dr. F. Allain (ETHZ)
- 01/16 – 06/17 SNI grant:
IgG Aptamer-Nanopartikel für die Entwicklung von Zelllinien für die Antikörperproduktion, together with Dr. Martin Held (ETHZ) and FGen
- 01/18 – 12/19 SNI grant:
Efficient capturing of mRNA for single-cell transcriptomics, together with Dr. Martin Held (ETHZ) and Memo Therapeutics
- 03/19 – 02/21 SNF Bridge Discovery:
Efficient Colonic Delivery, together with Prof. Dr. Georgios Imanidis (FHNW)
- 04/19 – 03/23 SNF:
Structural and Functional Characterisation of the Primer Synthesis of Archaeoeukaryotic Primases, together with Prof. Dr. F. Allain (ETHZ)
- 03/21 – 12/23 Innosuisse:
Targeted vitamin delivery to the microbiome for improved gut health, mit Prof. Dr. Georgios Imanidis (FHNW), Umsetzungspartner: DSM Nutritional Products
- 06/21 – 09/23 Innosuisse:
Plant virus diagnostics with novel conjugation strategy, mit Prof. Dr. Martin Sievers (ZHAW), Umsetzungspartner: Bioreba AG
- 04/22 - 09/24 Innosuisse:
A Novel Vaccine Platform for Antimicrobial Resistant Bacteria, Umsetzungspartner: LimmaTech
- 01/23 - 12/24 SNI:
SmartCoat - Innovative SmartCoats for efficient and targeted delivery of RNA-based therapeutics, mit Prof. J. Mosbacher (FHNW), Dr. R. Benoit (PSI) und Palto Therapeutics
Expertentätigkeiten
Editor for Plasmid, Member of the Editorial Board Extremophiles, Reviewer for Journals (NAR, Mol Microbiol, JMB, AEM, Biochemistry, etc.) and Funding Organisations (Innosuisse, DFG, ANR)
Laufbahn
Berufliche Laufbahn
CV
- Vordiplom (Bachelor) in Biology (University of Münster, 1989)
- Diplom (Master) in Biochemistry (University of Witten-Herdecke, 1992)
- Promotion (PhD) in Biochemistry Expression, Purification and Characterisation of schistosomal Cathepsin B, an immunodiagnostic antigen of Bilharziosis(University of Giessen, 1994)
- Scientist at the medical diagnostic company ScheBo Tech (Wettenberg, 1995-97)
- Group Leader at the Department of Biochemistry (University of Bayreuth, 1997-2003)
- Habilitation in Biochemistry The plasmid pRN1 from the thermoacidophilic archaeon Sulfolobus islandicus (University of Bayreuth, 2004)
- Assistant Professor at the Department of Biochemistry (University of Bayreuth, 2004-2007)
- Substitute Professor Biochemistry (University of Bayreuth, 2007-2008)
Institutional Repository