Tätigkeiten an der FHNW
- Arbeitsgruppenleiter Proteine und Enzyme
- Studiengangleiter MSc in Life Sciences
Forschung
Proteine: Expression, Charakterisierung, Engineering; Extremophile Mikroorganismen, Mikrobiom; Bioinformatische Auswertungen
Profil
Vordiplom (Bachelor) in Biology (University of Münster, 1989)
Diplom (Master) in Biochemistry (University of Witten-Herdecke, 1992)
Promotion (PhD) in Biochemistry Expression, Purification and Characteri-sation of schistosomal Cathepsin B, an immunodiagnostic antigen of Bilharziosis(University of Giessen, 1994)
Scientist at the medical diagnostic company ScheBo Tech (Wettenberg, 1995-97)
Group Leader at the Department of Biochemistry (University of Bayreuth, 1997-2003)
Habilitation in Biochemistry The plasmid pRN1 from the thermoacidophilic archaeon Sulfolobus islandicus (University of Bayreuth, 2004)
Assistant Professor at the Department of Biochemistry (University of Bayreuth, 2004-2007)
Substitute Professor Biochemistry (University of Bayreuth, 2007-2008)
: Influence of a nanoporous surface and of biofunctionalization upon biocompatibility towards bone cells, together with Prof. Dr. G. Ziegler (FBI, Bayreuth)
02/01 - 03/04 Grant by Bavarian high-tech initiative
: Production of thermostable and acidophilic enzymes for biotechnological purposes, together with Prof. G. Krauss (Department of Biochemistry, Bayreuth)
03/03 - 03/07 DFG grant, priority programme “Genome function and gene regulation in archaea”
: In vivo study of gene regulation and gene function in Sulfolobus ssp.: application and development of transformation vectors
02/04 - 01/07 DFG grant
: Structure and function of the gene products ORF8O and ORF904 from the plasmid pRN1 of the thermoacidophilic archaeon Sulfolobus islandicus
06/05 - 05/08 DFG grant
: Structure and function of the multifunctional replication protein from the plasmid pRN1 from Sulfolobus islandicus
10/06 - 09/09 DFG grant
: Study of an extremophilic β-endoglucanase
04/07 - 03/10 DFG grant
: Molecular mechanisms of archaeal DNA replication
04/12 - 12/15 SNF grant
: Structure and Function of a Primase, together with Prof. Dr. F. Allain (ETHZ)
12/12 – 09/15 CTI grant
: Identification of pharmacologic active compounds in the culture supernatant of a commensale E. coli, a commercial production, together with Laves AG
03/14 – 12/17 CTI grant
: Development of novel bacterial sortase enzymes for site-specific conjugation of payloads to antibodies, together with NBE Therapeutics
01/16 – 12/18 SNF grant
: Structure and Function of a Primase (prolongation), together with Prof. Dr. F. Allain (ETHZ)
01/16 – 06/17 SNI grant
: IgG Aptamer-Nanopartikel für die Entwicklung von Zelllinien für die Antikörperproduktion, together with Dr. Martin Held (ETHZ) and FGen
01/18 – 12/19 SNI grant
: Efficient capturing of mRNA for single-cell transcriptomics, together with Dr. Martin Held (ETHZ) and Memo Therapeutics
03/19 – 02/21 SNF Bridge Discovery
: Efficient Colonic Delivery, together with Prof. Dr. Georgios Imanidis (FHNW)
04/19 – 03/23 SNF
: Structural and Functional Characterisation of the Primer Synthesis of Archaeoeukaryotic Primases, together with Prof. Dr. F. Allain (ETHZ)
03/21 – 12/23 Innosuisse:Targeted vitamin delivery to the microbiome for improved gut health, mit Prof. Dr. Georgios Imanidis (FHNW), Umsetzungspartner: DSM Nutritional Products
06/21 – 09/23 Innosuisse:
Plant virus diagnostics with novel conjugation strategy, mit Prof. Dr. Martin Sievers (ZHAW), Umsetzungspartner: Bioreba AG
04/22 - 09/24 Innosuisse:
A Novel Vaccine Platform for Antimicrobial Resistant Bacteria, Umsetzungspartner: LimmaTech
01/23 - 12/24 SNI:
SmartCoat - Innovative SmartCoats for efficient and targeted delivery of RNA-based therapeutics, mit Prof. J. Mosbacher (FHNW), Dr. R. Benoit (PSI) und Palto Therapeutics
- Editor for Plasmid, Member of the Editorial Board Extremophiles, Reviewer for Journals (NAR, Mol Microbiol, JMB, AEM, Biochemistry, etc.) and Funding Organisations (Innosuisse, DFG, ANR)