Forschungsseminar: Lecture by Dr. Paul Engeroff, FHNW School of Life Sciences

Immunoglobulin E (IgE) is traditionally associated with immediate hypersensitivity through FcεRI-dependent activation of mast cells and basophils, but accumulating evidence indicates broader functions in regulating adaptive immune responses. Beyond its effector role in allergy, IgE can enhance antigen handling and amplify secondary humoral and cellular immunity, with outcomes shaped by antigen characteristics, IgE glycosylation, and differential engagement of IgE receptor pathways. In addition, naturally occurring IgG anti-IgE autoantibodies represent a feedback mechanism controlling IgE levels, limiting FcεRI sensitization, and promoting non-inflammatory clearance, with important implications for therapeutic anti-IgE vaccination strategies.

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