Protein engineering for therapeutic and diagnostic applications
Proteins, and enzymes in particular, are pivotal to a cell’s function. Protein engineering allows proteins to be optimised for technical applications.
Proteins can be produced in a lab using microorganisms. The proteins are purified and characterised in terms of their function. The function of proteins can then be optimised (e.g. the stability and activity of an enzyme) for use in technical applications using targeted mutagenesis or evolutive processes.
Research focus areas
- Protein expression
- Protein analytics and characterisation
- Protein engineering
- Bioinformatics
- Nucleic acid chemistry
- Microbiology of anaerobes and extremophiles
Equipment
- Flourescence spectrometry with stop-flow device
- Circular dichroism spectrometer
- UV-VIS spectrometer
- Microplate reader (absorbance and fluoresence)
- HPLC with diode array detector and fluoresence detector
- 2 dimensional mass spectrometer
- MALDI
- LICOR imager
- Fluorescence activated cell sorter (FACS)
- Protein chromatography
- Pipetting robot
- Ultracentrifuge
- Tangential flow filtration (TFF)
- Incubator for thermophiles
- Anaerobic glovebox
Publications
Contact
Prof. Dr. Georg Lipps
Dean MSc in Life Sciences,
Team leader Proteins and Enzymes
- Phone
- +41 61 228 54 52
- georg.lipps@fhnw.ch
Team
