Elbacoss

School of Life Sciences

Electrochemical bactericidal Ca(OH)2 implant coating as precursor for an osseoinductive HA layer

The rising number of periprosthetic infections has led to the development of various strategies for bactericidal implant coatings.

In this project we investigated the approach of an inorganic calcium hydroxide Ca(OH)₂ coating that expresses an initial antibacterial effect before it transforms into hydroxyapatite. Safety of this electrochemically deposited antimicrobial coating was shown preclinically, and the bactericidal effect was verified in-vitro.

Gallery

Preparation of the powder mixture using a Turbula mixer

EDX mapping of explants, from Evaluation of calcium dihydroxide- and silver-coated implants in the rat tibia

SEM image of a surface electrochemically coated with a lamellar Ca(OH)2-layer. From An inorganic antimicrobial surface modification for orthopaedic implants

Growth of S.aureus. a) Standardized Ca(OH)2-loaded tablets are used as positive control: growth is repressed in the inner ring. A diffusion ring extends to the outer ring, b) Uncoated Ti as a negative control: No impact to bacteria growth. c) Ca(OH)2-coated Ti: Complete inhibition in the close proximity, reduced bacteria growth in the diffusion zone. From An inorganic antimicrobial surface modification for orthopaedic implants

ELBACOSS-coated implant for preclinical study. From A new model of implant-related osteomyelitis in the metaphysis of rat tibiae

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Publications

Project details

Type: Research project
Research areas: Functional materials and surfaces
University: FHNW School of Life Sciences / Institute for Medical Engineering and Medical Informatics
Partner: Medicoat, Atesos, Fraunhofer, Empa, University of Basel, Technische Universität München,
Funding: Technopark Aargau, Forschungsfonds Aargau, SATW