Seminar Continuous Chromatography for Biotherapeutics

A profound introduction to continuous chromatography for mAbs, Oligonucleotides, Peptides and Viral Vectors.

Key data

Next start: 8.9.2026
Duration: 3 Days (8.-10.9.2026)
Teaching language: English
Place: FHNW Campus Muttenz
Fee: CHF 3’000

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The aim of this seminar is to provide an introduction to continuous chromatography with hands-on practice with capture and polishing processes for biomolecules. These processes lead to improvements in productivity and manufacturing costs while reducing environmental footprint. Attendees will acquire the basic tools to design, run and evaluate multicolumn processes and to quantify these improvements, serving as basis for an economic evaluation. As the least complex of all multicolumn processes, the workshop is focused on twin column chromatography.

Introduction to continuous chromatography for biomolecules
Theory of multi-column chromatography
Design of multi-column chromatography processes
Hands-on training on twin column equipment for capture and polishing applications
Process performance evaluation and scale-up
Introduction to process modelling

This workshop does not cover 4-zone SMB, chiral and small molecule separations.

Content

The seminar comprises presentations and interactive workshops using laboratory-scale Contichrom CUBE twin column separation & purification systems. Subject matter experts and graduate assistants will support the participants during the interactive workshops and data analysis sessions.

Day 1

Production of Biotherapeutics
Fundamentals of Large-molecule chromatography
Intro to Continuous Chromatography (CaptureSMB)
Lab workshop: CaptureSMB
Modelling and Simulation
Digitalization
Evening program / Dinner

Programme Day 1
09.00-09.10: Welcome and Housekeeping
09.10-09.45: Lecture 1 Production of Bio-Therapeutics
09.45-10.45: Lecture 2 Fundamentals of Large-Molecule Chromatography
10.45-11.00: Coffee break
11.00-12.30: Lab Workshop 1 Contichrom CUBE and Batch Capture
12.30-13.30: Lunch
13.30-14.15: Lecture 3 Continuous Countercurrent Chromatography
14.15-15.00: Lecture 4: Affinity (Capture) Chromatography
15.00-15.15: Coffee break
15.15-17.00: Lab Workshop 2 CaptureSMB
17.00-18.00: Lecture 5: Performance Evaluation of Continuous Chromatography
18.00: Reception

Day 2

Flowthrough and Frontal Chromatography
Integrated Chromatography
Continuous Chromatography: MCSGP
Lab workshop: MCSGP
Performance Evaluation
Lab workshop: CaptureSMB Evaluation
N-Rich
Evening program / Dinner

Programme Day 2
09.00-10.30: Lecture 6 Bind and Elute (Polishing) Chromatography
10.30-10.54: Coffee break
10.45-12.00: Lab Workshop 3 Linear Gradient Chromatography
12.00-13.00: Lunch
13.00-13.30: Lab Workshop 4 Evaluation Center
13.30-14.30: Lab Workshop 5 Evaluation of Batch and CaptureSMB
14.30-15.00: Presentation of Capture Results by Groups
15.00-15.15: Coffee break
15.15-17.30: Lab Workshop 6 MCSGP
17.30: Social programme + Dinner

Day 3

Modelling Workshop
Lab workshop: MCSGP Evaluation
Scale-up (MCSGP)
Wrap-up

Programme Day 3
09.00-10.30: Lecture 7 Integrated Continuous Manufacturing & Process Digitalization
10.30-10.45: Coffee break
10.45-12.00: Lecture 8 Modeling and Simulations
12.00-13.00: Lunch
13.00-14.00: Lab Workshop 7 Evaluation of MCSGP
14.00-14.30: Presentation of Polishing Results by Groups
14.30-15.15: Lecture 9-I Scale-up of continuous chromatography (part I)
15.15-15.30: Coffee break
15.30-16.15: Lecture 9-II Scale-up of continuous chromatography (part II), Guest Speaker: Ralf Eisenhuth, Bachem, Switzerland
16.15-16.45: Lecture 10 N-Rich Process for Isolation of Impurities
16.45-17.00: Course Wrap-up
17.00-17.30:Guided lab tour (optional)

Overview

Target Audience

This seminar is aimed at industry and academic separation scientists and process development engineers who already have some familiarity with single column chromatography and who want to broaden their understanding of chromatographic processes and look at new and more efficient ways to separate and polish biomolecules.

Format

Seminar fee

The seminar fee is CHF 3’000.
This includes lecture summaries in paper and electronic formats, materials used during the workshop, internet access (Wifi), lunch and coffee breaks as well as participation in the evening pro-gram/dinner. It does not include accommodation, travel costs or catering other than indicated above.

Seminar leaders

Massimo Morbidelli Ph.D., Professor of Chemical Reaction and Separation Technologies in the Department of Chemistry, Politecnico di Milano. A pioneer in preparative continuous chromatography and in particular in the application of multicolumn technologies for protein purification in the pharma industry, Prof. Morbidelli has co-authored over 500 research articles and four books. He serves as associate editor for the Industrial & Engineering Chemical Research journal of the ACS and is the recipient of the 2005
RH Wilhelm award from the AIChE and of the 2014 Gerhard Damkoehler medal of DECHEMA. He is a co-founder of ChromaCon AG in Zurich.

Thomas Müller-Späth, Ph.D., Director of RnD at ChromaCon AG in Zurich. After an assignment at Bayer Health-care, Thomas completed his doctoral work on continuous chromatography of biomolecules in the group of Prof. Morbidelli, and co-founded ChromaCon AG to bring the technology to the market. He has been working on research projects with industrial partners, development of chromatography processes and equipment, and IP management. He has presented on numerous workshops and conferences on continuous chromatography and has co-authored over 20 publications and patents.

Supervisors and tutors: Sebastian Vogg, Richard Weldon, Lars Aumann

Accommodation

Hotel Baslertor Muttenz

Hotel b_smart_motel Basel

Moevenpick Basel

Testimonials

PhD. Theresa Ahern, Eli Lilly (IE)

“The continuous chromatography seminar had an excellent balance of theoretical content and laboratory based exercises. It was great to explore the significant gains observed in productivity, buffer consumption and resin utilization over batch chromatography.”

PhD. Mercedes Ferreras, Novo Nordisk (DK)

“Great to learn all the potential and application of the different ways of using continuous chromatography and learn that this is not just a smart way of working in research, but that it can be implemented in large scale production.”

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Conditions of Participation Continuing Education Courses HLS