Engineering nanocarriers from material design to biological performance
We engineer nanoparticles to overcome biological barriers, enable the delivery of challenging biotherapeutics, and address hard-to-treat diseasess.
Our team is skilled at working with lipid, polymeric, and hybrid materials to produce nanocarriers. Inside, we can package cargo such as mRNA, peptides, proteins, and small molecules.
Our nanoparticles can be used to target cancer and antimicrobial-resistant infections, or be designed as sensing and diagnostic agents.
Research focus areas
Our research spans nanocarrier construction, nano–bio interactions, drug delivery, and translation to the clinic.
Nanocarrier engineering
Nano–biointerface engineering
Drug delivery and translation toward the clinic
Projects
Lipid-polymer hybrid nanoparticles (LPNPs)
Lipid-polymer hybrid nanoparticles (LPNPs) combine the cargo compatibility of lipid systems with the mechanical stability and processing opportunities of polymeric carriers.
We are developing an integrated platform for reproducible formulation, dry-state storage and scalable two-step manufacture of LPNPs. Our aim is to develop LPNPs that deliver mRNA through the lungs (inhalation).
- Design: combining the cargo, lipid, and polymer
- Interrogate: considering the structure, interface, and function
- Manufacture: ensuring stability and quality at scale
- Validate: measuring performance against infectious diseases and cancer
