Vectors for gene therapy, viral particles, loaded extracellular vesicles, and cellular disease models
Modern genetic engineering enables the production of cells tailored to specific applications. Genetic manipulation of patient cells using gene therapy vectors has now made it possible to correct the primary causes of monogenic diseases, and more than 20 gene therapy products have already received market approval. In addition, genetically modified cells are commonly used tools in biopharmaceutical research and production.
We develop gene therapy vectors and viral particles, as well as produce genetically modified cells for manufacturing or as cellular test systems. In addition, we are active in the targeted in vivo loading of extracellular vesicles with RNA and proteins and cell-cell communication via extracellular vesicles.
Expertise and infrastructure
- Safety of lentiviral vectors
- Targeted in vivo loading of extracellular vesicles with proteins and RNA for targeted cell-cell communication
- ddPCR (6 colours)
- Cell dispenser
- Electroporation
- Lentiviral vectors
- Gammaretroviral vectors
- CRISPR/Cas
Media
Publications
Contact
Prof. Dr. Ulrich Siler
- Phone
- +41 61 228 63 26
- ulrich.siler@fhnw.ch