A more secure and efficient screening technique for foracylcarnitines, amino acids and steroids in newborns by LC-MS
In Switzerland, 84’000 newborns are screened by dried blood spot analysis for innate errors every year [1-3]. However, traditional methods in this field are laborious as they are based on punching and offline extraction. Even more critically, sometimes sample confusion is caused electrostatic effects, which direct punched samples into the wrong tube or well. A method using steroids, acylcarnitines and amino acid based on the DBS-500 is presented here.
Workflow
Materials and methods
Results and discussion
Conclusions
Outlook
References
Project details
- Type
- Research project
- Research areas
- Instrumental analytics
- University
- FHNW School of Life Sciences / Institute for Chemistry and Bioanalytics
- Partner
- CAMAG Chemie-Erzeugnisse & Adsorptionstechnik AG; University Children's Hospital, Children’s Research Center, Swiss Newborn Screening Laboratory
- Collaboration
- Christian Berchtold, Irene Wegner, Stefan Gaugler, Tamara von Däniken, Markus Wyss, Ralph Fingerhut, Götz Schlotterbeck
Contact
Prof. Dr. Stefan Gaugler
Team Leader, Instrumental Analytics
- Phone
- +41 61 228 50 98
- stefan.gaugler@fhnw.ch