Oral formulations of chemical drugs, FHNW School of Life Sciences

We are active in the field of oral dosage forms for compounds that are poorly water-soluble. Our focus lies on lipid-based drug delivery systems as well as solid drug dispersions to target enhanced solubilization and absorption. Different formulation and process technologies are available at laboratory scale, including vacuum homogenization, micro particle prilling, hot melt extrusion, and spray drying.

New computer-based and analytical methods support a rational formulation design from molecular drug-excipient interactions to the microstructure of the final dosage form. Digital and analytical imaging approaches provide research tools to facilitate a modern version of Quality by Design for oral dosage forms.

• Amorphous solid formulations
• Mesoporous dosage forms
• Lipid-based formulations
• Molecular simulations in galenics
• Thermodynamic models and AI-supported drug formulations
• Laser-based methods for investigating drug solutions
• Spectroscopic methods for characterising solid forms
• Gas adsorption methods for solids
• Rheological methods for galenic analysis